Rapid developments in Artificial Intelligence are leading to an increasing human reliance on machine decision making. Even in collaborative efforts with Decision Support Systems (DSSs), where a human expert is expected to make the final decisions, it can be hard to keep the expert actively involved throughout the decision process. DSSs suggest their own solutions and thus invite passive decision making. To keep humans actively ‘on’ the decision-making loop and counter overreliance on machines, we propose a ‘reflection machine’ (RM). This (...) system asks users questions about their decision strategy and thereby prompts them to evaluate their own decisions critically. We discuss what forms RMs can take and present a proof-of-concept implementation of a RM that can produce feedback on users’ decisions in the medical and law domains. We show that the prototype requires very little domain knowledge to create reasonably intelligent critiquing questions. With this prototype, we demonstrate the technical feasibility to develop RMs and hope to pave the way for future research into their effectiveness and value. (shrink)

Selection on grandparental investment is more complex than Coall & Hertwig (C&H) propose. Patterns of investment are subject to an intergenerational conflict over how resources should be distributed to maximize fitness. Grandparents may be selected to distribute resources unevenly, while their descendants will be selected to manipulate investment in their own favor. Here we outline the evolutionary basis of this conflict.

Colour constancy refers to the ability to extract information about surface colours independently of illumination conditions. A ripe strawberry, for example, appears the same red when viewed under a blue sky or a reddish sunset. Since Land's pioneering work, discussion has centred on the issue whether colour constancy is achieved primarily in the retina or visual cortex. Recently, the debate has shifted to a consideration of the constraints imposed by various psychophysical tasks and instructions. Humans can judge illuminant colour, reflected-light (...) colour, surface colour, and the relationship between surface colours within a scene. Such observations suggest that colour constancy may not be a unitary phenomenon, and that its different aspects may be mediated at different levels in the visual system. Several questions therefore arise: are the tasks of surface estimation and illuminant estimation complementary, insofar as good performance in one implies poor performance in the other? How does retinal adaptation alter performance? Is colour vision tuned to the statistical composition of natural surfaces and illuminants? What role does colour-opponent processing in retina and cortex play in colour constancy? These and related questions are explored here in order to better understand what we mean when we ask: "Why do strawberries look red?". (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

What determines whether an action is right or wrong? Morality, Rules, and Consequences: A Critical Reader explores for students and researchers the relationship between consequentialist theory and moral rules. Most of the chapters focus on rule consequentialism or on the distinction between act and rule versions of consequentialism. Contributors, among them the leading philosophers in the discipline, suggest ways of assessing whether rule consequentialism could be a satisfactory moral theory. These essays, all of which are previously unpublished, provide students in (...) moral philosophy with essential material and ask key questions on just what the criteria for an adequate moral theory might be. (shrink)

Johanna Knapstein,1 Daniel Grimm,1 Marcus A Wörns,1 Peter R Galle,1 Hauke Lang,2 Tim Zimmermann111st Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany; 2Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg-University, Mainz, GermanyIntroduction: Hepatitis C virus reinfection occurs universally after liver transplantation, with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Dual antiviral therapy with pegylated interferon-2a and ribavirin only reaches sustained virological response rates of ~30% after liver transplantation. With the approval of viral NS3/4A (...) protease inhibitors telaprevir, boceprevir, and simeprevir and the NS5B polymerase inhibitor sofosbuvir, combination therapy offers new therapeutic options for HCV-infected patients, resulting in considerably higher sustained virological response rates in the nontransplant setting. Case presentation: We report three cases of TVR-based triple antiviral therapy in HCV genotype 1 reinfected patients after liver transplantation, of whom a 57-year-old Caucasian female and a 43-year-old Caucasian male were therapy naïve, and a 49-year-old Caucasian male patient was pretreated ineffectively. After 4 weeks of therapy, viral load decreased one to three log10 and became negative in weeks 6 to 8 in the therapy naïve patients. The pretreated patient showed a negative viral load in week 4. TVR was administered over 12 weeks, 750 mg thrice daily. Doses of immunosuppression with cyclosporine were reduced four to six fold. Initial peg-IFN and RBV doses ranged from 135–180 µg/week and 800–1,200 mg/day, according to the patient's body weight. Doses of peg-IFN and RBV were adapted to 90–135 µg/week and 400–800 mg/day after 2 to 12 weeks of protease inhibitor therapy. Dual therapy was continued for 36 weeks with total treatment duration of 48 weeks in the therapy naïve patients leading to a sustained virological response 12 weeks after the end of therapy. In the pretreated patient a breakthrough was detected in week 24 and therapy was discontinued. Overall, antiviral therapy was well tolerated. Side effects included dysgeusia and anemia leading to erythropoietin application and blood transfusions. Conclusion: This case series emphasizes that triple therapy with TVR is an efficient treatment for therapy naïve HCV genotype 1 reinfected patients after liver transplantation. But therapeutic options for pretreated patients require improvement. Keyword: cyclosporine, interferon, ribavirin, hepatitis C, protease inhibitor. (shrink)

W. K. Clifford was a noted mathematician and popularizer of science in the Victorian era. Although he made major contributions in the field of geometry, he is perhaps best known for a short essay he wrote in 1876, entitled The Ethics of Belief, in which he argued that It is wrong always, everywhere, and for any one, to believe anything upon insufficient evidence. Delivered initially as an address to the august Metaphysical Society (whose members included such luminaries as Alfred Lord (...) Tennyson, William Gladstone, T. H. Huxley, and assorted scientists, clerics and philosophers of differing metaphysical views, The Ethics of Belief became a rallying cry for freethinkers and a bone of contention for religious apologists. It continues to be discussed today as an exemplar of what is called 'evidentialism', a key point in current philosophy of religion debates over justification of knowledge claims. In this book, Timothy J. Madigan examines the continuing relevance of The Ethics of Belief to epistemological and ethical concerns. He places the essay within the historical context, especially the so-called 'Victorian Crisis of Faith' of which Clifford was a key player. Clifford's own life and interests are dealt with as well, along with the responses to his essay by his contemporaries, the most famous of which was William James's The Will to Believe. Madigan provides an overview of modern-day critics of Cliffordian evidentialism, as well as examining thinkers who were positively influenced by him, including Bertrand Russell, who was perhaps Clifford's most influential successor as an advocate of intellectual honesty. The book ends with a defense of The Ethics of Belief from a virtue-theory approach, and argues that Clifford utilizes an as-if methodology to encourage intellectual inquiry and communal truth-seeking.' The Ethics of Belief' continues to provoke and stimulate controversy, which was perhaps Clifford's own fondest hope, although he had no right to believe it would do so. (shrink)

"First published by Oxford University Press, 1916."--Title page verso.

First published in 1938. The aim of this book is to expound Kant’s _Critique of Judgement _by interpreting all the details in the light of what Kant himself declares to be his fundamental problem. _A Commentary on Kant’s Critique of Judgement _provides an excellent introduction to Kant’s third critique, and will be of interest to students of philosophy.

This paper defends the view of continuants as 'four-dimensional worms' against an argument of Geach's. This is to the effect that if continuants are four-dimensional worms then their stages either do, or do not, fall under the very general terms satisfied by the continuants themselves (a stage of a man either is, or is not, a man); but that either alternative is untenable. I try to show how the former alternative may be defended by appealing to some of Geach's own (...) ideas about identity; then go on to defend the four-dimensionalist view from a criticism of it by Mellor, and finish with an account of the intuitive distinction between process and continuant terms. (shrink)

Epistemische Notationen ist als Bezeichnung einer Schreibweise wie viele andere in der Philosophie gebräuchlichen Darstellungsmöglichkeiten eine Ausdrucks- und Redeeinführung. Dieselbe steht für eine sprachstufen- und typentheoretische Beschreibungsaltemative, die sowohl mit natürlicher Sprache als auch mit logisch-mathematischen Kalkülen verträglich ist. Vier Merkmale haben besonderes Gewicht: 1. E-Notationen (= Epistemische Notationen) sind wirklichkeitsrepräsentativ; 2. mengentheoretisch; 3. typentheoretisch; 4. sprachstufentheoretisch. Die durch Kombination dieser Charakteristika entstehende „Abstraktionszange" erlaubt es, normalsprachlich nicht faßbare „Interpretationskonstrukte" zu,,lokalisieren". Die Entstehungsgeschichte der,,Epistemischen Notationen" ist daher eng mit der Theorie (...) der Antinomienbildung verknüpft. Insofern ist dieser approach auch für antinomientheoretische Untersuchungenbesonders geeignet. Die sprachanalytische Verwendbarkeit dieses Ansatzes ist jedoch so allgemein, daß sich damit eine ganze Reihe schwer faßbarer philosophischer Probleme auf neue Weise analysieren lassen. Vor allem sind es Fragen der Bedeutung, Außersprachlichkeit und Selbstbezüglichkeit, die Begriffe wie,,exakt", „genau" oder „beweisbar" ins Licht einer zwar ungewohnten, aber kritisch befruchtenden Perspektive rücken. Epistemische Notationen sind deshalb ein erster Schritt zu einer realistischeren Einschätzung unserer künftigen philosophischen Möglichkeiten. (shrink)

Epistemische Notationen ist als Bezeichnung einer Schreibweise wie viele andere in der Philosophie gebräuchlichen Darstellungsmöglichkeiten eine Ausdrucks- und Redeeinführung. Dieselbe steht für eine sprachstufen- und typentheoretische Beschreibungsaltemative, die sowohl mit natürlicher Sprache als auch mit logisch-mathematischen Kalkülen verträglich ist. Vier Merkmale haben besonderes Gewicht: 1. E-Notationen (= Epistemische Notationen) sind wirklichkeitsrepräsentativ; 2. mengentheoretisch; 3. typentheoretisch; 4. sprachstufentheoretisch. Die durch Kombination dieser Charakteristika entstehende „Abstraktionszange" erlaubt es, normalsprachlich nicht faßbare „Interpretationskonstrukte" zu,,lokalisieren". Die Entstehungsgeschichte der,,Epistemischen Notationen" ist daher eng mit der Theorie (...) der Antinomienbildung verknüpft. Insofern ist dieser approach auch für antinomientheoretische Untersuchungenbesonders geeignet. Die sprachanalytische Verwendbarkeit dieses Ansatzes ist jedoch so allgemein, daß sich damit eine ganze Reihe schwer faßbarer philosophischer Probleme auf neue Weise analysieren lassen. Vor allem sind es Fragen der Bedeutung, Außersprachlichkeit und Selbstbezüglichkeit, die Begriffe wie,,exakt", „genau" oder „beweisbar" ins Licht einer zwar ungewohnten, aber kritisch befruchtenden Perspektive rücken. Epistemische Notationen sind deshalb ein erster Schritt zu einer realistischeren Einschätzung unserer künftigen philosophischen Möglichkeiten. (shrink)

There is preserved in Suidas' Lexicon a story about Polycrates of Samos and the island of Delos. It is offered by the lexicographer as an explanation of the phrase τατ σοι κα πύθια κα δλια , when used in a colloquial sense to mean ‘it's all the same to you’. Polycrates had instituted a festival on Delos and asked the Pythia whether to call it by the one name or the other. The phrase, which was supposed to have been the (...) Pythia's reply, was taken to mean that it was all the same to Polycrates whatever he called it, and the death of Polycrates, coming soon after, was interpreted as the fulfilment of the prophecy. Suidas cites Epicurus and Menander for the phrase itself, which was therefore in familiar use by the end of the fourth century B.C. As for the story about Polycrates, it is quite likely that Suidas' ultimate source was some writer of about that period, such as Demon, περ παροιμιν. It is very much in the manner of his fragments. (shrink)

British accounts of medical ethics concentrate on confidentiality to the exclusion of wider questions of privacy. This paper argues for consideration of privacy within medical ethics, and illustrates through the television series `Hospital', what may go awry when this wider concept is forgotten.

First published in 2002. Routledge is an imprint of Taylor & Francis, an informa company.